Make sure that you take a time off 4 weeks before you start with the new cycle of the supplement again. See to it that you do not take more than 3 grams of Kre-Alkalyn every day. For starters, although there is no loading phase, you should consider taking at least 1. You can compliment your Kre-Alkalyn intake with amino acid supplements and other bodybuilding supplements. Keep that in mind. Kre-alkalyn and other creatine risks can adversely affect kidney function if you have any condition.
The supplement has also been said to increase the risk for kidney stones. Well, there have been no reports on this to date. There will likely be studies to determine that at some point. I reviewed the product briefly and found no theoretical reason why anybody should be worried on that front. Creatine and Kre-Alkalyn, in particular, are great bodybuilding supplements, especially if you want to gain mass.
If you want to increase your training intensity, gain lean mass or are simply looking for that extra edge, Kre-Alkalyn is certainly worth giving a try! Thank you for this great information. I would recommend this article to my friends to help them with their activities. The effects of Kre Alkalyn improve the glycogen storage by the muscles. This stored glycogen works along with rehydration and […]. Save my name, email, and website in this browser for the next time I comment.
Gym Junkies. Nutrition Supplements. What side effects? What Is Creatine? Why Kre-Alkalyn? How much is right for each of the options? Read on. Do not use Kre-Alkalyn continuously! There are a lot of potential benefits to be had with this. But, as always, the big question is does it actually work? And, are there side effects? The short answer would be no. Another common question is does Kre-Alkalyn cause cancer?
Stay tuned! Conclusion Creatine and Kre-Alkalyn, in particular, are great bodybuilding supplements, especially if you want to gain mass. However, creatine development is moving at an unprecedented pace, with one such derivative flying under the radar for over five years. This version, known as Kre-Alkalyn, could be what you really need to see all that creatine promises to deliver.
Kre-Alkalyn is a pH corrected form of creatine, otherwise referred to as a buffered formulation. This form, designed to exist in an alkaline environment between on the pH scale, but most often existing at a pH of 12 , is argued to be better in terms of bioavailability and subsequent absorption rate.
Kre-Alkalyn is a patented ingredient belonging to the company All American Pharmaceutical. It was originally developed by Dr. The company holds patents to the ingredient in the US, Canada, Australia, and New Zealand-Alkalyn is today licensed to be used as the active ingredient in several popular brands across the market. The mechanism of action of Kre-Alkalyn is virtually identical to that of standard creatine monohydrate, with a few differences.
Basic creatine works to increase the availability of phosphocreatine in muscles PCr , which subsequently assists with the synthesis of adenosine triphosphate ATP from adenosine diphosphate ADP. Thus, creatine functions largely as a phosphate group donor to enable the resynthesis of ATP. Regular creatine monohydrate is severely restricted in what it can do, however, owing to its generally low bioavailability.
Kre-Alkalyn is not affected by acidic pH in the stomach and can facilitate more complete absorption. Training volume was calculated by multiplying the amount of weight lifted times the number of repetitions performed for each set performed. Total training volume during the study was analyzed by summing all lifts upper and lower body to determine if there were any differences among groups. Body composition testing occurred on day 0, 7 and 28 of the study.
Height and weight were recorded to the nearest 0. DEXA has been validated as an accurate method for body composition assessment [ 40 ]. Whole blood samples were analyzed for complete blood counts with platelet differentials using an Abbott Cell Dyn automated hematology analyzer Abbott Laboratories, Abbott Park, IL.
Muscle biopsies were obtained using a modified Bergstrom needle biopsy technique following standard procedures [ 42 ]. Muscle tissue samples were analyzed spectrophotometrically in duplicate for creatine Cr using methods developed by Harris and colleagues [ 7 , 8 , 43 ]. Connective tissue was removed from the dried samples which were then grinded into a powder in a porcelain plate and placed into pre-weighed microfuge tubes.
Muscle metabolites were extracted in a 0. The supernatant was transferred into a pre-weighed microfuge tube and neutralized with 2. Test to test reliability of duplicate muscle creatine assays was 0.
We also assayed muscle samples for phosphocreatine PCr but several values were out of normal ranges, there was large variability in values observed, and overall PCr levels declined over time despite creatine supplementation suggesting a lack of validity in this assay.
Therefore, these data were not reported. Rest recovery was standardized between attempts at 2-min and participants typically reached their 1RM within 3—5 attempts after warming up. Test-to-test reliability of performing these tests in our lab on resistance-trained participants have yielded low day to day mean coefficients of variation and high reliability for the bench press 1. The seat position was standardized between trials and the participant was asked to pedal as fast as possible prior to application of the workload and sprint at all-out maximal capacity during the second test.
Participants practiced the anaerobic capacity test during the familiarization session to minimize learning effects.
Compliance to the supplementation protocol was monitored by turning in empty weekly supplement containers, supplement logs and verbal confirmation. After completing the compliance procedures, subjects were given the required supplements and dosages for the following supplementation period. Greenhouse-Geisser univariate tests of within-subjects time and group x time effects and between-subjects univariate group effects were reported for each variable analyzed within the MANOVA model.
Data were considered statistically significant when the probability of type I error was 0. Forty-one participants were initially recruited for the study, completed consent forms and participated in the required familiarization session.
Of the original 41 participants, 36 completed the day research study. Three participants dropped out due to time constraints, one due to an unrelated illness, and one due to apprehension of the muscle biopsy procedure. None of the participants dropped out of the study due to side effects related to the study protocol. Table 3 shows the baseline demographics for the participants. Overall, participants were Table 4 shows the total training volumes for upper and lower body lifts.
Table 5 presents mean energy intake and macronutrient content for each group. MANOVA univariate analysis revealed a significant time effect suggesting that energy and protein intake tended to decrease during the study but no significant interactions were observed among groups. Similar results were observed when assessing energy and macronutrient intake when expressed relative to body mass.
Table 6 presents muscle free creatine content data while Figure 1 shows changes in muscle free content. Sufficient muscle samples were obtained to measure baseline and subsequent creatine on 25 participants. Subjects with missing baseline or day data were not included in the analysis. Two day-7 missing creatine values were replaced using the last observed value method.
No significant groups x time interactions were observed among groups. Table 7 presents body composition results observed during the study while Figure 2 shows the changes observed over time in fat free mass and percent body fat. Bodyweight increased in all groups over time 1. Fat-free mass significantly increased over time for all groups 0. Table 8 shows upper and lower body 1RM strength data observed for each group while Figure 3 shows the changes in 1RM bench press. There was a significant increase in 1RM for bench press in all groups over time However, values remained low and near baseline.
Table 11 shows markers of catabolism and bone status. Table 12 presents serum electrolyte data. Finally, Table 12 shows whole blood markers assessed throughout the study. The purpose of this study was to determine if supplementing the diet with recommended 1. Additionally, the study was undertaken to determine whether supplementing the diet with recommended or equivalent creatine doses of a purported buffered form of creatine was associated with fewer side effects in comparison to creatine monohydrate.
Because of this fact, an accepted method of assessing whole body creatine retention has been to subtract daily urinary creatine excretion from daily dietary intake of creatine [ 32 , 33 , 45 — 47 ]. Additionally, while it is true that generally the lower the pH and higher the temperature, the greater conversion of creatine to creatinine, studies show that this process takes several days to occur at significant levels even when creatine is exposed to low pH environments [ 1 , 19 , 48 ].
As described in a recent review [ 1 ], the degradation of creatine can be reduced or even halted by either lowering the pH to under 2. A very high pH results in the deprotonation of the acid group, thereby slowing down the degradation process by making it more difficult for the intramolecular cyclization of creatine to creatinine. However, a very low pH as is the case in the stomach results in the protonation of the amide function of the creatine molecule, thereby preventing the intramolecular cyclization of creatine to creatinine [ 1 ].
This is the reason that the conversion of creatine to creatinine in the gastrointestinal tract has been reported to be minimal regardless of transit time [ 7 , 18 , 20 ]. Results of the present study do not support claims that a large amount of creatine monohydrate was converted to creatinine during the digestive process and thereby resulted in less of an increase in muscle creatine than KA.
In this regard, while serum creatinine levels increased to a greater degree in the KA-H and CrM groups that ingested larger amounts of creatine, the 0. Therefore, this small change would be clinically insignificant.
Additionally, a significant increase from baseline in serum creatinine was also observed in the KA-L and KA-H groups despite claims that KA completely prevents the conversion of creatine to creatinine. These findings do not support contentions that CrM is degraded to creatinine in large amounts or that KA is not converted to creatinine at all.
Prolonged low-dose ingestion of CrM e. The manufacturer of KA claims that ingesting 1.
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